HIF-1α is transcriptionally regulated by NF-κB in acute kidney injury
Zuo‐Lin Li, Jialing Ji, Yi Wen, Jing-Yuan Cao, Naresh Kharbuja, Wei‐Jie Ni, Di Yin, Songtao Feng, Hong Liu, Lin‐Li Lv, Bi‐Cheng Liu, Bin Wang
Abstract
Here, the mechanism of hypoxia-inducible factor-α (HIF-α) regulation in acute kidney injury (AKI) was investigated. We found that tubular HIF-1α expression significantly increased at the transcriptional level, which was closely associated with macrophage-dependent inflammation. Meanwhile, NF-κB was involved in the increasing expression of HIF-1α in AKI. Mechanistically, NF-κB directly bound to the HIF-1α promoter and enhanced its transcription. Our findings not only provide novel insights into HIF-1 regulation in AKI but also offer to understand the pathophysiology of kidney diseases.
Topics & Concepts
Acute kidney injuryTranscription factorNF-κBPathophysiologyKidneyInflammationHypoxia (environmental)Transcription (linguistics)Cell biologyNFKB1Cancer researchBiologyMedicineGeneChemistryImmunologyInternal medicineGeneticsOrganic chemistryPhilosophyLinguisticsOxygenCancer, Hypoxia, and MetabolismImmune cells in cancerPeroxisome Proliferator-Activated Receptors