Acute interleukin-6 modulates key enzymes involved in prefrontal cortex and hippocampal amyloid precursor protein processing
Daniel M. Marko, Michael S. Finch, Alex Yang, L Castellani, Willem T. Peppler, David C. Wright, Rebecca E. K. MacPherson
Abstract
It is becoming evident that exercise modulates APP processing and can reduce amyloid-beta (Aβ) peptide production. Our data help to explain this phenomenon by highlighting IL-6 as an exercise-induced factor that lowers pathological APP processing. These results also highlight brain regional differences in response to acute IL-6.
Topics & Concepts
ADAM10Amyloid precursor proteinHippocampal formationAmyloid precursor protein secretaseEndocrinologyHippocampusInternal medicineAmyloid betaChemistryMetalloproteinaseMedicineAlzheimer's diseaseMatrix metalloproteinaseDiseaseDisintegrinStress Responses and CortisolTryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms