Optimization of Artificial Siderophores as <sup>68</sup>Ga-Complexed PET Tracers for In Vivo Imaging of Bacterial Infections
Carsten Peukert, Laura N. B. Langer, Sophie M. Wegener, Anna Tutov, Jens P. Bankstahl, Bianka Karge, Frank M. Bengel, Tobias L. Roß, Mark Brönstrup
Abstract
and were able to discern infection from lipopolysaccharide-triggered, sterile inflammation. The study qualifies cyclen-based artificial siderophores as readily accessible scaffolds for the in vivo imaging of bacteria.
Topics & Concepts
SiderophoreIn vivoChemistryBacteriaEscherichia coliCyclenMolecular imagingPet imagingPositron emission tomographyRadiochemistryPreclinical imagingGalliumBiochemistryBiophysicsStereochemistryBiologyNuclear medicineMedicineGeneticsOrganic chemistryGeneBiotechnologyAntibiotic Resistance in BacteriaRadiopharmaceutical Chemistry and ApplicationsPneumocystis jirovecii pneumonia detection and treatment