Hypocrellin B-based activatable photosensitizers for specific photodynamic effects against high H<sub>2</sub>O<sub>2</sub>-expressing cancer cells
Takashi Kitamura, Hirotaka Nakata, Daisuke Takahashi, Kazunobu Toshima
Abstract
A purpose-designed synthetic H 2 O 2 -activatable photosensitizer 4 based on hypocrellin B (3) exhibited selective photo-cytotoxicity against target cancer cells upon photo-irradiation with highly tissue penetrating 660 nm light.
Topics & Concepts
PhotosensitizerPhotodynamic therapyChemistryCytotoxicityPhotochemistryAbsorption (acoustics)In vitroMaterials scienceBiochemistryOrganic chemistryComposite materialNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesPorphyrin and Phthalocyanine Chemistry