Novel oxygen-generation from electrospun nanofibrous scaffolds with anticancer properties: synthesis of PMMA-conjugate PVP–H<sub>2</sub>O<sub>2</sub> nanofibers, characterization, and <i>in vitro</i> bio-evaluation tests
Samar A. Salim, Elbadawy A. Kamoun, Stephen D. Evans, Tarek H. Taha, Esmail M. El‐Fakharany, Mohamed M. Elmazar, A. F. Abdel-Aziz, Radwa H. Abou‐Saleh, Taher A. Salaheldin
Abstract
, after 2.5 h). PMMA-10% PHP nanofibers provided an ideal model for released-oxygen scaffold with anti-cancer effect and high selectivity for cancer cells, especially for breast cancer cells. Nanofibrous scaffolds with different composition revealed high cell viability for normal cells. Such outcomes support the suitability of using synthesized nanofibrous scaffolds as released-oxygen biomaterials to enhance cancer cells' sensitivity and maximize the treatment effect.
Topics & Concepts
NanofiberElectrospinningHydrogen peroxidePolyvinylpyrrolidoneChemical engineeringOxygenChemistrySwellingMaterials sciencePolymerPolymer chemistryNuclear chemistryNanotechnologyComposite materialOrganic chemistryEngineeringElectrospun Nanofibers in Biomedical ApplicationsPolymer Nanocomposite Synthesis and IrradiationBone Tissue Engineering Materials