CD73 induces GM-CSF/MDSC-mediated suppression of T cells to accelerate pancreatic cancer pathogenesis
Ryan J. King, Surendra K. Shukla, Chunbo He, Enza Vernucci, Ravi Thakur, Kuldeep S. Attri, Aneesha Dasgupta, Nina V. Chaika, Scott E. Mulder, Jaime Abrego, Divya Murthy, Venugopal Gunda, Camila G. Pacheco, Paul M. Grandgenett, Audrey J. Lazenby, Michael A. Hollingsworth, Fang Yu, Kamiya Mehla, Pankaj K. Singh
Topics & Concepts
Pancreatic cancerCancer researchImmune systemBiologyGene knockdownIn vivoCytokineKnockout mouseEx vivoPancreatic tumorAdenosineGemcitabineAdenocarcinomaCancer cellCytotoxic T cellSuppressorTumor microenvironmentT cellCancerPancreasPathogenesisDownregulation and upregulationApoptosisImmunotherapyMetastasisAntibodyCell growthEndocrinologyCell cultureTransforming growth factorAdenosine and Purinergic SignalingImmune cells in cancerNeutrophil, Myeloperoxidase and Oxidative Mechanisms