New anti-viral drugs for the treatment of COVID-19 instead of favipiravir
Ahmet Hamdi Aktaş, Burak Tüzün, Rukiye Aslan, Koray Sayın, Hilmi Ataseven
Abstract
-pyrazine-3-carboxamide performed better than favipiravir in the results of molecular docking, molecular mechanics Poisson-Boltzmann surface area (MM-PSBA) calculations, and ADME analyses.Communicated by Ramaswamy H. Sarma.
Topics & Concepts
FavipiravirPubChemADMEVirologyDruggabilityAutoDockRNA polymeraseDocking (animal)Small moleculePharmacologyVirusComputational biologyChemistryDrugRNABiologyIn silicoMedicineCoronavirus disease 2019 (COVID-19)BiochemistryDiseaseInfectious disease (medical specialty)GeneNursingPathologyComputational Drug Discovery MethodsSARS-CoV-2 and COVID-19 Researchthermodynamics and calorimetric analyses