Continuous-flow Si–H functionalizations of hydrosilanes <i>via</i> sequential organolithium reactions catalyzed by potassium <i>tert</i>-butoxide
Hyune‐Jea Lee, Changmo Kwak, Dong‐Pyo Kim, Heejin Kim
Abstract
We herein report an atom-economic flow approach to the selective and sequential mono-, di-, and tri-functionalizations of unactivated hydrosilanes <italic>via</italic> serial organolithium reactions catalyzed by earth-abundant metal compounds.
Topics & Concepts
CatalysisOrganolithium compoundsPotassiumChemistryFlow chemistryMetalContinuous flowAtom (system on chip)Combinatorial chemistryOrganic chemistryMedicinal chemistryBiochemical engineeringComputer scienceEngineeringIonEmbedded systemDeprotonationCatalytic Cross-Coupling ReactionsOrganoboron and organosilicon chemistryAsymmetric Hydrogenation and Catalysis