Characterization of <i>In Vitro</i> Resistance to Linezolid in Mycobacterium abscessus
Dereje A. Negatu, Wassihun Wedajo Aragaw, Véronique Dartois, Thomas Dick
Abstract
. We found, as expected, resistance mutations in the ribosome. In addition, we identified mutations in a system that involves a drug pump, suggesting drug efflux as a mechanism of resistance to linezolid. This finding may inform the analysis of clinical resistance to linezolid. Surprisingly, a subset of linezolid-resistant ribosome mutations conferred cross-resistance to several structurally and mechanistically unrelated drugs, uncovering a novel multidrug resistance mechanism.
Topics & Concepts
LinezolidMycobacterium abscessusMicrobiologyAntibioticsMycobacteriumLung diseaseIn vitroBacteriaPulmonary diseaseMedicineBiologyLungGeneticsStaphylococcus aureusInternal medicineVancomycinMycobacterium research and diagnosisTuberculosis Research and EpidemiologyInfectious Diseases and Mycology