Myricitrin – a flavonoid isolated from the Indian olive tree (<i>Elaeocarpus floribundus</i>) – inhibits Monoamine oxidase in the brain and elevates striatal dopamine levels: therapeutic implications against Parkinson's disease
Chayan Banerjee, Sumangal Nandy, Joy Chakraborty, Deepak Kumar
Abstract
. However, only myricitrin inhibited MAO in the mouse brain and elevated dopamine levels. Myricitrin was able to attenuate motor incoordination in the mouse model of PD and improved dopamine levels in the striatum.
Topics & Concepts
DopamineMonoamine oxidaseDopaminergicPharmacologyMonoamine oxidase BIn vivoChemistryMonoamine neurotransmitterBiochemistryBiologyEnzymeSerotoninEndocrinologyBiotechnologyReceptorParkinson's Disease Mechanisms and TreatmentsElectrochemical sensors and biosensorsBiochemical and biochemical processes