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Buspirone ameliorates premature ovarian insufficiency evoked by cyclophosphamide in female rats; attention to AMPK/Nrf2/HO-1, α-Klotho/NLRP3/Caspase-1, and Caspase-3-mediated apoptosis interplay

Waleed A.I. Khallaf, Ehab E Sharata, Mina Ezzat Attya, Remon Roshdy Rofaeil, Marwa M. Khalaf, Ramadan A.M. Hemeida, Amira M. Abo‐Youssef

2025Toxicology and Applied Pharmacology19 citationsDOI

Topics & Concepts

Estrous cycleApoptosisEndocrinologyInternal medicinePremature ovarian failurePyroptosisWestern blotOxidative stressCaspase 3IcariinOvariectomized ratAMPKInflammasomePharmacologyAndrologyMedicineBiologyHormoneInflammationProgrammed cell deathCell biologyPhosphorylationProtein kinase AGeneBiochemistryAlternative medicinePathologyEndometriosis Research and TreatmentChemotherapy-induced organ toxicity mitigationReproductive Biology and Fertility
Buspirone ameliorates premature ovarian insufficiency evoked by cyclophosphamide in female rats; attention to AMPK/Nrf2/HO-1, α-Klotho/NLRP3/Caspase-1, and Caspase-3-mediated apoptosis interplay | Litcius