Synthesis and biological evaluation of novel aromatic amide derivatives as potential BCR-ABL inhibitors
Xiu Jun Wang, Zhou Xu, Jing Feng, Gang Pan, Xingbei He, Mingxiao Lv, Huijie Chen, Wentao Jiang, Jing Ji, Mingli Yang
Topics & Concepts
ChemistryK562 cellsABLImatinibKinaseImatinib mesylateIC50AmideMyeloid leukemiaChronic myelogenous leukemiabreakpoint cluster regionPharmacologyLeukemiaIn vitroCancer researchBiochemistryTyrosine kinaseSignal transductionInternal medicineReceptorMedicineChronic Myeloid Leukemia TreatmentsChronic Lymphocytic Leukemia ResearchProtein Degradation and Inhibitors