Novel benzo[4,5]thiazolo[2,3-C][1,2,4]triazoles: Design, synthesis, anticancer evaluation, kinase profiling and molecular docking study
Ahmed H. Abdelazeem, Alaa M. Alqahtani, Hany H. Arab, Ahmed M. Gouda, Asmaa G. Safi El-Din
Topics & Concepts
ChemistryDocking (animal)KinaseMoietyLead compoundStereochemistryCytotoxicityEGFR inhibitorsA549 cellCancer cellIsatinBiochemistryEpidermal growth factor receptorApoptosisIn vitroReceptorCancerOrganic chemistryMedicineNursingInternal medicineClick Chemistry and ApplicationsSynthesis and biological activityCancer Mechanisms and Therapy