Discovery of 2-((2-methylbenzyl)thio)-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of sepsis
Xuetao Chen, Fanying Meng, Jingtian Zhang, Zijian Zhang, Xuan Ye, Weikun Zhang, Yuanyuan Tong, Xinrui Ji, Rujun Xu, Xiaoli Xu, Qidong You, Zhengyu Jiang
Topics & Concepts
SepsisBromodomainChemistryPharmacologyIn vivoThio-Cancer researchBiochemistryInternal medicineEpigeneticsStereochemistryMedicineBiologyBiotechnologyGeneProtein Degradation and InhibitorsHistone Deacetylase Inhibitors ResearchImmune Cell Function and Interaction