Discovery of sertraline and its derivatives able to combat drug-resistant gastric cancer cell via inducing apoptosis
Chao Mu, Rui-Kun Peng, Chunling Guo, Ao Li, Xiuming Yang, Rong Zeng, Yulong Li, Jing Gu, Qin Ouyang
Topics & Concepts
ChemistryApoptosisDrug repositioningPharmacologyDrugIC50CancerCancer cellPI3K/AKT/mTOR pathwayProgrammed cell deathCell growthCell cycle checkpointRepurposingCell cycleIn vitroBiochemistryMedicineBiologyInternal medicineEcologyCancer therapeutics and mechanismsDrug Transport and Resistance MechanismsCancer Mechanisms and Therapy