Developmental Immaturity of Siglec Receptor Expression on Neonatal Alveolar Macrophages Predisposes to Severe Group B Streptococcal Infection
Sean Lund, Kathryn A. Patras, Jacqueline M. Kimmey, Asami Yamamura, Lindsay D. Butcher, Pamela G.B. Del Rosario, Gilberto E. Hernandez, Alyssa M. McCoy, Omar Lakhdari, Victor Nizet, Lawrence S. Prince
Abstract
mice both impaired GBS clearance. AMΦ engage the heavily sialylated GBS capsule via the cell surface Siglec receptors Sn and Siglec-E. Although both newborn and adult ΑΜΦ expressed Siglec-E, newborn ΑΜΦ expressed significantly lower levels of Sn. We propose that a developmental delay in Sn expression on ΑΜΦ may prevent effective killing and clearing of GBS from the newborn lung.
Topics & Concepts
SIGLECStreptococcus agalactiaeImmunologyStreptococcusPneumoniaBiologyNeonatal sepsisGroup BLegionella pneumophilaStreptococcus pneumoniaeReceptorPhagocytosisSepsisLungMicrobiologyImmune systemMedicineInternal medicineBacteriaAntibioticsBiochemistryGeneticsNeonatal and Maternal InfectionsStreptococcal Infections and TreatmentsPreterm Birth and Chorioamnionitis