Proanthocyanidins from Chinese bayberry leaves reduce obesity and associated metabolic disorders in high-fat diet-induced obese mice through a combination of AMPK activation and an alteration in gut microbiota
Yu Zhang, Haibo Pan, Xingqian Ye, Shiguo Chen
Abstract
. BLPs also reduced the circulated endotoxin and maintained the gut barrier's integrity. Further antibiotic treatment revealed that depleting the gut microbiota abrogated the anti-obesogenic effects of BLPs, yet did not affect AMPK activation. Collectively, these results suggest that BLPs reduce obesity and associated metabolic disorders in HFD-fed mice through a combination of AMPK activation and an alteration in gut microbiota.
Topics & Concepts
Gut floraAMPKDownregulation and upregulationDysbiosisBiologyEndocrinologyInternal medicineImmunologyBiochemistryMedicineProtein kinase AKinaseGeneGut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesDietary Effects on Health