Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity
Rocío Recio, Patricia Lerena, Esther Pozo, José Manuel Calderón‐Montaño, Estefanía Burgos‐Morón, Miguel López‐Lázaro, Victoria Valdivia, Manuel Pernía Leal, Bernard Mouillac, Juan Ángel Organero, Noureddine Khiar, Inmaculada Fernández
Abstract
I] SP from NK1R). Interestingly, this galactosyl derivative has shown marked selective cytotoxic activity against 12 different types of cancer cell lines.
Topics & Concepts
ChemistryIn vitroGalactoseAntagonistCarbohydrateCisplatinStereochemistryBiological activityCytotoxicityBiochemistryReceptorChemotherapyMedicineSurgeryBioactive Compounds and Antitumor AgentsCancer therapeutics and mechanismsImmune Cell Function and Interaction