Pyridazinones containing the (4-methoxyphenyl)piperazine moiety as AChE/BChE inhibitors: design, synthesis, in silico and biological evaluation
İrem Bozbey Merde, Gülce Taşkor Önel, Burçin Türkmenoğlu, Şule Gürsoy, Esra Dilek
Topics & Concepts
AcetylcholinesteraseChemistryAchéAcetylcholinePiperazineStereochemistryMoietyDocking (animal)In silicoCholinergicLead compoundPharmacologyEnzymeBiochemistryIn vitroInternal medicineOrganic chemistryMedicineNursingGeneCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsEnzyme function and inhibition