Customized blood-brain barrier shuttle peptide to increase AAV9 vector crossing the BBB and augment transduction in the brain
Xintao Zhang, Zheng Chai, Amanda L. Dobbins, Michelle S. Itano, Charles Askew, Zhe Miao, Hongqian Niu, R. Jude Samulski, Chengwen Li
Topics & Concepts
Transduction (biophysics)TranscytosisBlood–brain barrierBiologySystemic administrationAdeno-associated virusGenetic enhancementPeptideCell biologyViral vectorIn vivoVirologyRecombinant DNAPharmacologyMolecular biologyVector (molecular biology)Central nervous systemReceptorNeuroscienceBiochemistryGeneGeneticsEndocytosisVirus-based gene therapy researchRNA Interference and Gene DeliveryRNA regulation and disease