Diamine-mediated degradative dimerisation of Morita–Baylis–Hillman ketones
Ajit Kumar Jha, Anju Kumari, Srinivasan Easwar
Abstract
A degradative dimerisation of Morita-Baylis-Hillman ketones was observed in the presence of a primary diamine. The reaction proceeded swiftly to produce methylene-bridged 1,3-dicarbonyl compounds. A brief mechanistic investigation alluded to a retro-Mannich reaction as the key step of the transformation.
Topics & Concepts
DiamineChemistryMethyleneBaylis–Hillman reactionTransformation (genetics)Organic chemistryCatalysisCombinatorial chemistryBiochemistryGeneAsymmetric Synthesis and CatalysisSynthesis and Catalytic ReactionsCatalytic C–H Functionalization Methods