Lipid Metabolism Genes in Stroke Pathogenesis: The Atherosclerosis
Yit‐Lai Chow, Lai Kuan Teh, Loh Huey Chyi, Li Fang Lim, Chin Chu Yee, Loo Keat Wei
Abstract
Stroke is the second leading cause of death and a major cause of disability worldwide. Both modifiable and non-modifiable risk factors can affect the occurrence of ischemic stroke at varying degrees. Among them, atherosclerosis has been well-recognized as one of the main culprits for the rising incidence of stroke-related mortality. Hence, the current review aimed to summarize the prominent role of lipid metabolism genes such as PCSK9, ApoB, ApoA5, ApoC3, ApoE, and ABCA1 in mediating ischemic stroke occurrence.
Topics & Concepts
Stroke (engine)MedicineLipid metabolismPathogenesisIncidence (geometry)Cause of deathApolipoprotein EIschemic strokePCSK9BioinformaticsGeneABCA1Internal medicineDiseaseCholesterolBiologyIschemiaLipoproteinGeneticsLDL receptorTransporterPhysicsOpticsEngineeringMechanical engineeringCancer, Lipids, and MetabolismLipoproteins and Cardiovascular HealthPeroxisome Proliferator-Activated Receptors