CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities
Kyuho Han, Sarah E. Pierce, Amy Li, Kaitlyn Spees, Grace R. Anderson, José A. Seoane, Yuan‐Hung Lo, Michael M. Dubreuil, Micah Olivas, Roarke A. Kamber, Michael Wainberg, Kaja Kostyrko, Marcus R. Kelly, Maryam Yousefi, Scott W. Simpkins, David Yao, Keonil Lee, Calvin J. Kuo, Peter K. Jackson, E. Alejandro Sweet‐Cordero, Anshul Kundaje, Andrew J. Gentles, Christina Curtis, Monte M. Winslow, Michael C. Bassik
Topics & Concepts
CRISPRBiologyCancerComputational biologyLung cancerPhenotypeSpheroidCancer researchCancer cellGeneGeneticsPathologyMedicineIn vitroCRISPR and Genetic EngineeringSingle-cell and spatial transcriptomicsAdvanced biosensing and bioanalysis techniques