Litcius/Paper detail

CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities

Kyuho Han, Sarah E. Pierce, Amy Li, Kaitlyn Spees, Grace R. Anderson, José A. Seoane, Yuan‐Hung Lo, Michael M. Dubreuil, Micah Olivas, Roarke A. Kamber, Michael Wainberg, Kaja Kostyrko, Marcus R. Kelly, Maryam Yousefi, Scott W. Simpkins, David Yao, Keonil Lee, Calvin J. Kuo, Peter K. Jackson, E. Alejandro Sweet‐Cordero, Anshul Kundaje, Andrew J. Gentles, Christina Curtis, Monte M. Winslow, Michael C. Bassik

2020Nature334 citationsDOIOpen Access PDF

Topics & Concepts

CRISPRBiologyCancerComputational biologyLung cancerPhenotypeSpheroidCancer researchCancer cellGeneGeneticsPathologyMedicineIn vitroCRISPR and Genetic EngineeringSingle-cell and spatial transcriptomicsAdvanced biosensing and bioanalysis techniques
CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities | Litcius