The synthesis and anti‐tumour properties of novel 4-substituted phthalazinones as Aurora B kinase inhibitors
Xiujuan Zhang, Yu Xu, Hong-Xia Mou, Shuai Wang, Shu-Yi Hao, Shi‐Wu Chen
Topics & Concepts
ChemistryAurora B kinaseAurora inhibitorAurora kinaseIC50Cyclin-dependent kinase 1KinaseApoptosisDocking (animal)Cell cycle checkpointCell cycleTrifluoromethylStereochemistryPhosphorylationBiochemistryCellIn vitroCell divisionAlkylSpindle apparatusMedicineNursingOrganic chemistryMicrotubule and mitosis dynamicsCancer-related Molecular PathwaysUbiquitin and proteasome pathways