Neratinib exerts dual effects on cartilage degradation and osteoclast production in Osteoarthritis by inhibiting the activation of the MAPK/NF-κB signaling pathways
Jianxin Qiu, Ting Jiang, Guangyong Yang, Yuhang Gong, Weikang Zhang, Xiaohang Zheng, Zhenghua Hong, Haixiao Chen
Topics & Concepts
OsteoclastChemistryCell biologyCartilageMAPK/ERK pathwayRANKLNeratinibOsteoarthritisCancer researchSignal transductionInternal medicineBiochemistryBiologyMedicineIn vitroAnatomyActivator (genetics)PathologyReceptorCancerBreast cancerAlternative medicineTrastuzumabInflammatory mediators and NSAID effectsBone Metabolism and DiseasesOsteoarthritis Treatment and Mechanisms