Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2
Miao Zheng, Bo Feng, Yumin Zhang, Xin Liu, Na Zhao, Hui Liu, Zichao Xu, Xinheng He, Zhiyan Qu, Shizhao Chen, Zhidong Jiang, Xi Cheng, Hong Liu, Yi Zang, Linxiang Zhao, Jie Zheng, Leike Zhang, Jia Li, Yu Zhou
Topics & Concepts
PapainSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ProteaseSmall moleculeCoronavirus disease 2019 (COVID-19)Chemistry2019-20 coronavirus outbreakCovalent bondDrug discoveryComputational biologyVirologyEnzymeBiochemistryPharmacologyCombinatorial chemistryBiologyMedicineOrganic chemistryPathologyOutbreakInfectious disease (medical specialty)DiseaseDiverse Scientific Research StudiesComputational Drug Discovery MethodsSARS-CoV-2 and COVID-19 Research