No association between frailty index and epigenetic clocks in Italian semi-supercentenarians
Maria Giulia Bacalini, Davide Gentilini, Daniela Monti, Paolo Garagnani, Daniela Mari, Matteo Cesari, Giulia Ogliari, Giuseppe Passarino, Claudio Franceschi, Chiara Pirazzini, Beatrice Arosio
Abstract
Centenarians experience successful ageing, although they still present high heterogeneity in their health status. The frailty index is a biomarker of biological age, able to capture such heterogeneity, even at extreme old age. At the same time, other biomarkers (e.g., epigenetic clocks) may be informative the biological age of the individual and potentially describe the ageing status in centenarians. In this article, we explore the relationship between epigenetic clocks and frailty index in a cohort of Italian centenarians. No association was reported, suggesting that these two approaches may describe different aspects of the same ageing process.