ICAM-1 mediated cell-cell adhesion exerts dual roles on human B cell differentiation and IgG production
Shuai Liu, Zhi-cui Liu, Meiyu Zhang, Shujun Wang, Meng Pan, Ping Ji, Cheng Zhu, Ping Lin, Ying Wang
Abstract
T-B cell adhesion provides dual roles on B cell differentiation and IgG production partially depending on expression levels of PD-1 on B cells, supporting cell adhesion and subsequent PD-1 induction as an alternative intrinsic checkpoint for B cell differentiation.
Topics & Concepts
Cell biologyCell adhesionICAM-1Cell adhesion moleculeCellular differentiationChemistryB cellCD28Naive B cellT cellCellCD40AdhesionBiologyImmunologyAntibodyAntigen-presenting cellCytotoxic T cellImmune systemIn vitroBiochemistryOrganic chemistryGeneCell Adhesion Molecules ResearchMonoclonal and Polyclonal Antibodies ResearchGalectins and Cancer Biology