Antihypertensive activity of the ACE–renin inhibitory peptide derived from<i>Moringa oleifera</i>protein
Keer Ma, Yujiao Wang, Mingjie Wang, Zhigao Wang, Xuefeng Wang, Xingrong Ju, Rong He
Abstract
models, LGF and GLFF significantly reduced the systolic blood pressure (19.4 mmHg; 18.2 mmHg) and diastolic blood pressure (12 mmHg; 13.8 mmHg) of SHRs (spontaneously hypertensive rats). The peptide transmembrane transport experiments and simulated gastrointestinal digestion experiments with LGF and GLFF showed that they can resist gastrointestinal digestion in a complete form. Thus, bioactive peptides from MO leaf may possess the potential to be used for treating hypertension in humans.
Topics & Concepts
HydrolysateChemistryUltrafiltration (renal)PeptideRenin–angiotensin systemEnzymeAngiotensin-converting enzymeIC50Amino acidPharmacologyBiochemistryHydrolysisChromatographyBlood pressureInternal medicineIn vitroMedicineProtein Hydrolysis and Bioactive PeptidesMoringa oleifera research and applicationsAquaculture Nutrition and Growth