Anodic Oxidation of Dithiane Carboxylic Acids: A Rapid and Mild Way to Access Functionalized Orthoesters
Anthony D. Garcia, Matthew C. Leech, Alessia Petti, Camille Denis, Iain C. A. Goodall, Adrian P. Dobbs, Kevin Lam
Abstract
A new electrochemical methodology has been developed for the preparation of a wide variety of functionalized orthoesters under mild and green conditions from easily accessible dithiane derivatives. The new methodology also offers an unprecedented way to access tri(fluorinated) orthoesters, a class of compound that has never been studied before. This provides the community with a rapid and general method to prepare libraries of functionalized orthoesters from simple and readily available starting materials.
Topics & Concepts
ChemistryDithianeCombinatorial chemistryElectrochemistryAnodic oxidationOrganic chemistryElectrodePhysical chemistryRadical Photochemical ReactionsOxidative Organic Chemistry ReactionsElectrochemical Analysis and Applications