Tumor Targeting by α<sub>v</sub>β<sub>3</sub>-Integrin-Specific Lipid Nanoparticles Occurs <i>via</i> Phagocyte Hitchhiking
Alexandros Marios Sofias, Yohana C. Toner, Anu E. Meerwaldt, Mandy M. T. van Leent, Georgios Soultanidis, Mattijs Elschot, Haruki Gonai, Kristin Grendstad, Åsmund Flobak, Ulrike Neckmann, Camilla Wolowczyk, Elizabeth L. Fisher, Thomas Reiner, Catharina de Lange Davies, Geir Bjørkøy, Abraham J. P. Teunissen, Jordi Ochando, Carlos Pérez‐Medina, Willem J. M. Mulder, Sjoerd Hak
Abstract
-integrin-targeted cyclic arginine-glycine-aspartate decorated liposomes and oil-in-water nanoemulsions in tumor mouse models. We observed that ligand-mediated accumulation in cancerous lesions is multifaceted and identified "NP hitchhiking" with phagocytes to contribute considerably to this intricate process. We anticipate that this understanding can facilitate rational improvement of nanomedicine applications and that immune cell-NP interactions can be harnessed to develop clinically viable nanomedicine-based immunotherapies.