Impact of rilpivirine cross-resistance on long-acting cabotegravir-rilpivirine in low and middle-income countries
Kim Steegen, Nomathemba Chandiwana, Simiso Sokhela, François Venter, Lucia Hans
Abstract
Baseline rilpivirine drug resistance mutations (DRMs) are a risk factor for virological failure in patients treated with long-acting cabotegravir and rilpivirine (CAB/RPV LA). We investigated rilpivirine cross-resistance in treatment-naive and experienced patients in South Africa. One in 10 treatment-naive patients and 74.5% of patients failing treatment presented with rilpivirine DRMs. Our data suggest targeted genotyping may be required for patients initiating CAB/RPV LA, which significantly complicates the currently used public health approach.
Topics & Concepts
RilpivirineMedicineDrug resistanceGenotypingInternal medicineVirologyHuman immunodeficiency virus (HIV)Antiretroviral therapyBiologyGenotypeViral loadGeneticsGeneHIV/AIDS drug development and treatmentRespiratory viral infections researchHIV Research and Treatment