A Lysozyme Murein Hydrolase with Broad-Spectrum Antibacterial Activity from Enterobacter Phage myPSH1140
Ramesh Nachimuthu, Prasanth Manohar, Kandasamy Eniyan, Archana Loganathan, Sudarsanan Athira, Belinda Loh, Long Ma, Sebastián Leptihn
Abstract
Bacteriophages and bacteriophage-derived peptidoglycan hydrolases (endolysins) present promising alternatives for the treatment of infections caused by multidrug resistant Gram-negative and Gram-positive pathogens. In this study, Gp105, a putative lysozyme murein hydrolase from Enterobacter phage myPSH1140 was characterized in silico, in vitro as well as in vivo using the purified protein.
Topics & Concepts
LysinPeptidoglycanLysozymeBiologyMicrobiologyBacteriophageEnterobacter cloacaeEnterobacterGram-negative bacteriaCitrobacter freundiiEscherichia coliBiochemistryEnzymeEnterobacteriaceaeGeneBacteriophages and microbial interactionsGenomics and Phylogenetic StudiesAntibiotic Resistance in Bacteria