Combined Maternal Immune Activation and Prenatal Intermittent Hypoxic Stress Lead to Developmental Motor Deficits in Rats: a Two-hit Animal Model for Cerebral Palsy Across Different Age Trajectories
Prosper Iwhiwhu, Benneth Ben‐Azu, Bienose S. Chijioke, Esther O. Ozah, Faith B. Friday, Daniel T. Esuku, Miracle Kii Nekabari, Ayereoghene S. Moses, Erubasa G. Oborhoghene, Abayomi M. Ajayi, Christian I. Uruaka
Topics & Concepts
OffspringMedicinePrepulse inhibitionCerebral palsyPrenatal stressNeurotrophic factorsCholinergicInternal medicineHypoxia (environmental)EndocrinologyPathophysiologyGestationOxidative stressInflammationPrefrontal cortexNeurologyPregnancyNeurodevelopmental disorderImmune systemCognitive declinePsychologyAnimal modelDopamineBrain-derived neurotrophic factorLipid peroxidationNeurotransmitterNeuroscienceNeonatal and fetal brain pathologyNeurological Disease Mechanisms and TreatmentsCerebral Palsy and Movement Disorders