Process optimization for acid-amine coupling: a catalytic approach
Ranjitsinh C. Dabhi, Unnati P. Patel, Vaibhavi B. Rathod, Siddharth Shah, Jayesh J. Maru
Abstract
Proficient routes were devised for coupling different aromatic/aliphatic acids with amines to form amide linkage using various catalysts. Under the optimized reaction conditions, highest conversion was possible without formation of any by-products. All synthesized compounds were purified using column chromatography and characterized by mass spectrometry, nuclear magnetic resonance spectrometry and liquid chromatography-mass spectrometric analysis.
Topics & Concepts
ChemistryAmideMass spectrometryCatalysisAmine gas treatingChromatographyCoupling (piping)Organic chemistryEngineeringMechanical engineeringChemical Synthesis and AnalysisChemical Synthesis and ReactionsSynthetic Organic Chemistry Methods