Initial IL-10 production dominates the therapy of mesenchymal stem cell scaffold in spinal cord injury
Lijun Yang, Jian Cao, Yiwen Du, Xunqi Zhang, Wenxiang Hong, Bowen Peng, Jiahe Wu, Qinjie Weng, Jiajia Wang, Jianqing Gao
Abstract
Our findings highlight a novel role of IL-10 in regulating MSC migration and cytokine secretion-associated programs, and determine the vital role of IL-10 in the domination of MSC treatment for spinal cord repair.
Topics & Concepts
Mesenchymal stem cellSpinal cord injuryMedicineHyaluronic acidSpinal cordCytokineImmune systemRegeneration (biology)Stem-cell therapyImmunologyCell biologyCancer researchNeuroscienceBiologyPathologyAnatomyPsychiatrySpinal Cord Injury ResearchMesenchymal stem cell researchNerve injury and regeneration