Glutamatergic neurons in lateral hypothalamus play a vital role in acupuncture preconditioning to alleviate MIRI
Qi Shu, Shuai-ya Wang, Pian-Pian Chen, Fan Zhang, Qianyi Wang, Xia Wei, Jie Zhou, Xiang Zhou, Qing Yu, Rong-Lin Cai
Abstract
This study demonstrates that EA preconditioning can attenuate myocardial injury for MIRI, which is similar to inhibition of glutamatergic neurons in LH. However, chemical activation of glutamatergic neurons in LH attenuates the protective effect of EA pretreatment. These findings help better understand the mechanisms of EA to regulate cardiac function.
Topics & Concepts
GlutamatergicElectroacupunctureGlutamate receptorHypothalamusNeuroscienceMedicineLateral hypothalamusInternal medicinePharmacologyChemistryBiologyReceptorAcupuncturePathologyAlternative medicineAcupuncture Treatment Research StudiesHeart Rate Variability and Autonomic ControlVagus Nerve Stimulation Research