Emerging Trends in Cancer Drug Discovery—From Drugging the “Undruggable” to Overcoming Resistance
Joachim Rudolph, Jeff Settleman, Shiva Malek
Abstract
Technology advancement and the courage to challenge dogma have been key elements that have continuously shifted druggability limits. We illustrate this notion with several recent cancer drug-discovery examples, while also giving an outlook on the opportunities offered by newer modalities such as chemically induced proximity and direct targeting of RNA. Treatment resistance is a major impediment to the goal of durable efficacy and cure, but the confluence of new biological insights, novel drug modalities, and drug combinations is predicted to enable transformative progress in this decade and beyond.
Topics & Concepts
DruggabilityDrug discoveryModalitiesTransformative learningCancer drugsDrug resistanceComputational biologyDrugComputer scienceMedicineBioinformaticsBiologyPharmacologyPsychologyGeneticsSociologyPedagogyGeneSocial scienceProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysHistone Deacetylase Inhibitors Research