Bispecific antibodies targeting mutant<i>RAS</i>neoantigens
Jacqueline Douglass, Emily Han-Chung Hsiue, Brian J. Mog, Michael S. Hwang, Sarah R. DiNapoli, Alexander H. Pearlman, Michelle S. Miller, Katharine M. Wright, P. Aitana Azurmendi, Qing Wang, Suman Paul, A. Schaefer, Andrew D. Skora, Marco Dal Molin, Maximilian F. Konig, Qiang Liu, Evangeline Watson, Yana Li, Michael Murphy, Drew M. Pardoll, Chetan Bettegowda, Nickolas Papadopoulos, Sandra B. Gabelli, Kenneth W. Kinzler, Bert Vogelstein, Shibin Zhou
Abstract
genes provided strong genetic evidence for the specificity of the scDbs. Thus, this approach could be applied to other common oncogenic mutations that are difficult to target by conventional means, allowing for more specific anticancer therapeutics.
Topics & Concepts
Phage displayAntibodyMutantBiologyAntigenContext (archaeology)Human leukocyte antigenMolecular biologyAlleleMutationCancer researchGeneGeneticsPaleontologyMonoclonal and Polyclonal Antibodies ResearchCAR-T cell therapy researchT-cell and B-cell Immunology