Ancestral reconstruction of mammalian FMO1 enables structural determination, revealing unique features that explain its catalytic properties
Gautier Bailleul, Callum R. Nicoll, María Laura Mascotti, Andrea Mattevi, Marco W. Fraaije
Abstract
binding domain instead of being stretched out in the solvent. Overall, the ancestrally reconstructed mammalian AncFMO1 serves as the first structural model to corroborate and rationalize the catalytic properties of FMO1.
Topics & Concepts
MonooxygenaseFlavin groupBiologyCofactorBiochemistryFlavin-containing monooxygenaseOxidoreductaseStructural similarityFlavin mononucleotideFlavin adenine dinucleotideProtein structureBinding siteEnzymeStereochemistryGeneticsChemistryCytochrome P450Pharmacogenetics and Drug MetabolismPharmaceutical and Antibiotic Environmental ImpactsMicrobial bioremediation and biosurfactants