2-Anilinopyrimidine derivatives: Design, synthesis, in vitro anti-proliferative activity, EGFR and ARO inhibitory activity, cell cycle analysis and molecular docking study
Omaima M. Aboulwafa, Hoda G. Daabees, Waleed A. Badawi
Topics & Concepts
ChemistryDocking (animal)IC50EGFR inhibitorsEpidermal growth factor receptorCell cycle checkpointEnzymeActive siteMTT assayAnnexinApoptosisCytotoxicityCell growthIn vitroStereochemistryCell cycleBiochemistryReceptorMedicineNursingSynthesis and biological activityComputational Drug Discovery MethodsCytokine Signaling Pathways and Interactions