2-Anilino-4-(1-methyl-1H-pyrazol-4-yl)pyrimidine-derived CDK2 inhibitors as anticancer agents: Design, synthesis & evaluation

Biruk Sintayehu Fanta, Laychiluh Mekonnen, Sunita K. C. Basnet, Theodosia Teo, Jimma Likisa Lenjisa, Nishat Zareen Khair, Lianmeng Kou, Solomon Tadesse, Matthew J. Sykes, Mingfeng Yu, Shudong Wang

2023Bioorganic & Medicinal Chemistry18 citationsDOI Open Access PDF

Topics & Concepts

Cyclin-dependent kinaseChemistryCyclin-dependent kinase 2KinaseCDK inhibitorPharmacologyCancer researchCell cycleStereochemistryApoptosisBiochemistryBiologyCancer-related Molecular PathwaysAdvanced Breast Cancer TherapiesCancer Mechanisms and Therapy

2-Anilino-4-(1-methyl-1H-pyrazol-4-yl)pyrimidine-derived CDK2 inhibitors as anticancer agents: Design, synthesis &amp; evaluation

Topics & Concepts

2-Anilino-4-(1-methyl-1H-pyrazol-4-yl)pyrimidine-derived CDK2 inhibitors as anticancer agents: Design, synthesis & evaluation