FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle
M. Zaeem Cader, Rodrigo Pereira de Almeida Rodrigues, James A. West, Gavin W. Sewell, Muhammad N. Md-Ibrahim, Stephanie Reikine, Giuseppe Sirago, Lukas Unger, Ana Belén Iglesias-Romero, Katharina Ramshorn, Lea-Maxie Haag, Svetlana Saveljeva, Jana‐Fabienne Ebel, Philip Rosenstiel, Nicole C. Kaneider, James Lee, Trevor D. Lawley, Allan Bradley, Gordon Dougan, Yorgo Modis, Julian L. Griffin, Arthur Kaser
Abstract
(Cell 180, 278–295.e1–e23, January 23, 2020) Due to a production error, the last name of author Ana Belén Iglesias-Romero was misspelled as “Inglesias-Romero.” This error has been corrected online, and we apologize for any confusion we may have caused. FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide CycleCader et al.CellJanuary 23, 2020In BriefDisease-linked, orphan FAMIN is an evolutionarily conserved, multifunctional purine nucleoside enzyme, with not only ADA-, PNP-, and MTAP-like activities but also adenosine phosphorylase activity. FAMIN enables a purine nucleotide cycle that balances the cytoplasmic-mitochondrial redox interface and prevents cytoplasmic acidification. Full-Text PDF Open Access