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Design, synthesis and biological evaluation of novel fluoro-substituted benzimidazole derivatives with anti-hypertension activities

Zhuo Wu, Ming-Bao Xia, D. Bertsetseg, Yanhui Wang, Xiaolu Bao, Weibo Zhu, Tao-Xu, Pei-Ran Chen, Hesheng Tang, Yi‐Jia Yan, Zhilong Chen

2020Bioorganic Chemistry49 citationsDOI

Topics & Concepts

BenzimidazoleChemistryLosartanTelmisartanAngiotensin II receptor type 1PharmacologyBlood pressureAngiotensin IIAntihypertensive drugBiological activityAngiotensin receptorReceptorCombinatorial chemistryStereochemistryBiochemistryInternal medicineOrganic chemistryIn vitroMedicineReceptor Mechanisms and SignalingComputational Drug Discovery MethodsSynthesis and Catalytic Reactions
Design, synthesis and biological evaluation of novel fluoro-substituted benzimidazole derivatives with anti-hypertension activities | Litcius