<i>In vivo</i> evaluation of compliance mismatch on intimal hyperplasia formation in small diameter vascular grafts
Yuan Yao, Grace Pohan, Marie F.A. Cutiongco, YeJin Jeong, Joshua Kunihiro, Aung Moe Zaw, Dency David, Hanyue Shangguan, Alfred C. H. Yu, Evelyn K. F. Yim
Abstract
patency. Two groups of PVA small diameter grafts with low compliance and high compliance were fabricated by dip casting method and implanted in a rabbit carotid artery end-to-side anastomosis model for 4 weeks. We demonstrated that the grafts with compliance that more closely matched with rabbit carotid artery had lower anastomotic intimal hyperplasia formation and higher graft patency compared to low compliance grafts. Overall, this study suggested that reducing the compliance mismatch between the native artery and vascular grafts is beneficial for reducing intimal hyperplasia formation.
Topics & Concepts
Intimal hyperplasiaAnastomosisCompliance (psychology)HyperplasiaIn vivoBiocompatibilityCarotid arteriesMedicineArteryThrombosisSurgeryPathologyChemistryInternal medicineBiologySmooth muscleOrganic chemistryBiotechnologyPsychologySocial psychologyElectrospun Nanofibers in Biomedical ApplicationsAortic Disease and Treatment ApproachesTissue Engineering and Regenerative Medicine