The discovery of novel small molecule allosteric activators of aldehyde dehydrogenase 2
Wei Tian, Jiapeng Guo, Qingsen Zhang, Shao‐Yu Fang, Ruolan Zhou, Jian Hu, Mingping Wang, Yuefan Zhang, Jin‐Min Guo, Zhuo Chen, Jü Zhu, Canhui Zheng
Topics & Concepts
ALDH2ChemistryAllosteric regulationAldehyde dehydrogenaseVirtual screeningIn vivoOxidative stressSmall moleculeLigand (biochemistry)Drug discoveryPharmacologyBiochemistryEnzymeReceptorMedicineBiologyGeneticsAlcohol Consumption and Health EffectsMetabolomics and Mass Spectrometry StudiesEicosanoids and Hypertension Pharmacology