Recent advances in understanding assembly of the primary cilium membrane
Saurabh Shakya, Christopher J. Westlake
Abstract
Ciliogenesis describes the assembly of cilia in interphase cells. Several hundred proteins have been linked to ciliogenesis, which proceeds through a highly coordinated multistage process at the distal end of centrioles requiring membranes. In this short review, we focus on recently reported insights into the biogenesis of the primary cilium membrane and its association with other ciliogenic processes in the intracellular ciliogenesis pathway.
Topics & Concepts
CiliogenesisCiliumCentrioleCell biologyBiogenesisInterphaseBasal bodyBiologyChemistryMicrotubuleBiochemistryFlagellumGeneGenetic and Kidney Cyst DiseasesProtist diversity and phylogenyRenal and related cancers