Allogeneic FLT3 CAR T Cells with an Off-Switch Exhibit Potent Activity against AML and Can Be Depleted to Expedite Bone Marrow Recovery
Cesar Sommer, Hsin‐Yuan Cheng, Duy Nguyen, Danielle Dettling, Yik A. Yeung, Janette Sutton, Moustafa Hamze, Julien Valton, Julianne Smith, Ivana M. Djuretic, Javier Chaparro‐Riggers, Barbra J. Sasu
Topics & Concepts
Chimeric antigen receptorBone marrowCancer researchMyeloid leukemiaMedicineLeukemiaHaematopoiesisImmunologyProgenitor cellImmunotherapyStem cellBiologyImmune systemGeneticsCAR-T cell therapy researchVirus-based gene therapy researchImmune Cell Function and Interaction