Effects of leg immobilization and recovery resistance training on skeletal muscle-molecular markers in previously resistance-trained versus untrained adults
Jonathan Michel, Joshua S. Godwin, Daniel L. Plotkin, Mason C. McIntosh, Madison L. Mattingly, Philip J. Agostinelli, Breanna J. Mueller, Derick A. Anglin, Nicholas J. Kontos, Alexander C. Berry, Marina Meyer Vega, Autumn A. Pipkin, Matt S. Stock, Zachary Graham, Harsimran S. Baweja, C. Brooks Mobley, Marcas M. Bamman, Michael D. Roberts
Abstract
Formerly trained and untrained individuals demonstrate similar atrophic responses to disuse while untrained individuals exhibited a greater hypertrophic response to subsequent resistance training. The molecular responses accompanying these changes were largely similar between groups and included increases in satellite cell content with resistance training and increases in ribosome biogenesis, which was largely driven by the formerly trained group.