Factor associated with oral candidiasis caused by co-infection of Candida albicans and Candida glabrata: A retrospective study
Hiroyuki Hato, Ken‐ichiro Sakata, Jun Sato, Akira Hasebe, Yutaka Yamazaki, Yoshimasa Kitagawa
Abstract
This study aimed to determine the factors associated with the co-infection of Candida albicans and Candida glabrata. This retrospective study conducted between January 2015 and 2020 comprised 131 patients who were diagnosed with oral candidiasis. The factors associated with this condition were analyzed by univariate and multivariate logistic regression. Age and denture use were identified as significant risk factors in the univariate analysis. The multivariate logistic regression analysis revealed that denture use (odds ratio [OR], 8.44 95% confidence interval [CI], 1.99–28.3) and immunosuppressive therapy (OR, 9.20; 95% CI, 1.19–62.0) had significant effects on co-infection with the two Candida species. These findings suggest that immunosuppressive therapy using and dentures is significantly associated with oral candidiasis caused by co-infection of C. albicans and C. glabrata.